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Stroke, Vol 19, 631-633, Copyright © 1988 by American Heart Association

ARTICLES

Altered leukocyte rheology in patients with chronic cerebrovascular disease

I Vermes and F Strik
Department of Clinical Chemistry, H.d.K. Hospital, Oldenzaal, The Netherlands.

Erythrocyte and leukocyte suspensions were prepared from 28 patients with chronic cerebrovascular disease and 30 age- and concomitant disease-matched control subjects. Cell filterability was studied with the new St. George's filtrometer, which can discriminate between initial filtration rate as an erythrocyte parameter and filter clogging as a leukocyte parameter. Compared with control subjects, a significant increase of filter clogging was found in the patients, suggesting decreased deformability or increased adhesiveness of leukocytes or both in chronic cerebrovascular disease.

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