This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vinge, E. Articles by Andersson, K. E. Search for Related Content PubMed PubMed Citation Articles by Vinge, E. Articles by Andersson, K. E.

Stroke, Vol 19, 644-647, Copyright © 1988 by American Heart Association

ARTICLES

Thromboxane B2 levels in serum during continuous administration of nimodipine to patients with aneurysmal subarachnoid hemorrhage

E Vinge, L Brandt, B Ljunggren and KE Andersson
Department of Clinical Pharmacology, University Hospital, Lund, Sweden.

Twenty-four patients with subarachnoid hemorrhage due to rupture of a supratentorial aneurysm underwent surgery within 72 hours after subarachnoid hemorrhage. Immediately after clipping of the aneurysm the patients were treated with intravenous nimodipine for at least 7 days and then received the drug orally for another week. Nine patients had a documented or probable intake of aspirin or other nonsteroid anti- inflammatory drug during the days preceding admission. In all patients there was a gradual increase in serum thromboxane B2 concentration from low to normal levels during the treatment period, the increase being most pronounced in patients with prior nonsteroid anti-inflammatory drug intake. Thromboxane B2 concentrations were similar to those of four control patients not receiving nimodipine. In three patients who developed delayed ischemic dysfunction despite "therapeutic" nimodipine plasma concentrations, the thromboxane B2 levels were low or normal. Our present results do not support the idea that nimodipine exerts an effect on platelet function in patients with aneurysmal subarachnoid hemorrhage.

This article has been cited by other articles:

				S. M. Dorhout Mees, G. J.E. Rinkel, J. W. Hop, A. Algra, and J. van Gijn Antiplatelet Therapy in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review Stroke, September 1, 2003; 34(9): 2285 - 2289. [Abstract] [Full Text] [PDF]

				J. van Gijn and G. J. E. Rinkel Subarachnoid haemorrhage: diagnosis, causes and management Brain, February 1, 2001; 124(2): 249 - 278. [Abstract] [Full Text] [PDF]

				J. W. Hop, G. J. E. Rinkel, A. Algra, J. W. B. van der Sprenkel, and J. van Gijn Randomized pilot trial of postoperative aspirin in subarachnoid hemorrhage Neurology, February 22, 2000; 54(4): 872 - 878. [Abstract] [Full Text] [PDF]