This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kochanek, P. M. Articles by Hallenbeck, J. M. Search for Related Content PubMed PubMed Citation Articles by Kochanek, P. M. Articles by Hallenbeck, J. M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB HEPARIN INDOMETHACIN

Stroke, Vol 19, 693-699, Copyright © 1988 by American Heart Association

ARTICLES

Effects of prostacyclin, indomethacin, and heparin on cerebral blood flow and platelet adhesion after multifocal ischemia of canine brain

PM Kochanek, AJ Dutka, KK Kumaroo and JM Hallenbeck
Diving Medicine Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.

Seven anesthetized dogs treated with prostaglandin I2, indomethacin, and heparin were compared with 12 controls to test the hypothesis that the salutary effect of treatment on recovery of neuronal function and cerebral blood flow (CBF) after ischemia is coupled to the inhibition of platelet accumulation. In this model of right hemisphere multifocal ischemia, cortical somatosensory evoked response (CSER) amplitude, 14C autoradiographic blood flow, and 111In-labeled platelet accumulation were measured. The ratio of injured to noninjured hemispheric 111In activity (cpm/g) provided an index of platelet accumulation. Treatment improved CBF of the injured hemisphere compared with control after 4 hours of reperfusion (74 +/- 17 versus 53 +/- 13 ml/100 g/min, p less than 0.05), and it enhanced recovery of CSER amplitude (percent of baseline) after 1 hour of reperfusion compared with control (27.1 +/- 4.7% [treatment] versus 15.5 +/- 2.8% [control], p less than 0.05). However, the effect on CSER was not sustained after 4 hours of recovery. Despite these effects on CSER and CBF, treatment failed to inhibit 111In-labeled platelet accumulation in the injured hemisphere (1.7 +/- 0.3% [treatment] versus 1.5 +/- 0.1% [control], p greater than 0.05). Platelets may adhere to damaged endothelium despite aggressive platelet antiaggregant therapy.

This article has been cited by other articles:

				J. M. Silakova, J. A. Hewett, and S. J. Hewett Naproxen Reduces Excitotoxic Neurodegeneration in Vivo with an Extended Therapeutic Window J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 1060 - 1066. [Abstract] [Full Text] [PDF]

				D. C. Morris, L. Zhang, Z. G. Zhang, M. Lu, K. L. Berens, P. M. Brown, and M. Chopp Extension of the Therapeutic Window for Recombinant Tissue Plasminogen Activator With Argatroban in a Rat Model of Embolic Stroke Stroke, November 1, 2001; 32(11): 2635 - 2640. [Abstract] [Full Text] [PDF]

				T. Najarian, P. Hardy, X. Hou, J. Lachapelle, A. Doke, F. Gobeil Jr., M.-S. Roy, P. Lachapelle, D. R. Varma, and S. Chemtob Preservation of neural function in the perinate by high PGE2 levels acting via EP2 receptors J Appl Physiol, August 1, 2000; 89(2): 777 - 784. [Abstract] [Full Text] [PDF]

				K. Soga, H. Fujita, T. Andoh, and F. Okumura Retinal Artery Air Embolism in Dogs: Fluorescein Angiographic Evaluation of Effects of Hypotension and Hemodilution Anesth. Analg., May 1, 1999; 88(5): 1004 - 1010. [Abstract] [Full Text] [PDF]

				T. F. Choudhri, B. L. Hoh, R. A. Solomon, E. S. Connolly Jr, and D. J. Pinsky Use of a Spectrophotometric Hemoglobin Assay to Objectively Quantify Intracerebral Hemorrhage in Mice Stroke, November 1, 1997; 28(11): 2296 - 2302. [Abstract] [Full Text]

				K. H. Ryu, B. J. Hindman, D. K. Reasoner, and F. Dexter Heparin Reduces Neurological Impairment After Cerebral Arterial Air Embolism in the Rabbit Stroke, February 1, 1996; 27(2): 303 - 310. [Abstract] [Full Text]