Stroke, Vol 19, 802-812, Copyright © 1988 by American Heart Association
E Mori, M Tabuchi, T Yoshida and A Yamadori
Intracarotid urokinase infusion therapy was performed on 22 patients with
evolving cerebral infarction due to acute thromboembolic occlusion of the
middle cerebral artery. Mean time from onset of symptoms to start of
infusion and mean dosage of urokinase were 4.5 hours and 927,000 units,
respectively. Immediate recanalization was achieved in 10 patients (45%)
after urokinase therapy. In patients with successful recanalization, rapid
amelioration of symptoms followed the restoration of blood flow.
Thrombolytic recanalization was associated with reduction of neurologic
deficits and of computed tomography- demonstrable infarction volume. The
reduction of infarction volume and functional outcome correlated highly
with the degree of reflow. Hemorrhagic transformation of infarction
occurred in four patients and controllable extracranial bleeding in three
patients. These results support the safety and efficacy of urokinase
therapy for acute thromboembolic occlusion of the middle cerebral artery.
ARTICLES
Intracarotid urokinase with thromboembolic occlusion of the middle cerebral artery
Neurology Service, Hyogo Brain and Heart Center, Himeji, Japan.
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|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 J. C Grotta Prevention and management of stroke Vascular Medicine, March 1, 1991; 2(1): 3 - 17. [PDF]
|
|
|
|
|
|
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|
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