Stroke, Vol 19, 820-825, Copyright © 1988 by American Heart Association
DM Reed, JA Resch, T Hayashi, C MacLean and K Yano
Atherosclerosis in the circle of Willis and its major branches was studied
prospectively in 198 men in the Honolulu Heart Program who were free of
cardiovascular disease at the entry examination. The level of
atherosclerosis was greater in the large arteries of the circle of Willis
than in the small arteries, and autopsy-verified cerebral infarction was
strongly associated with increasing severity of atherosclerosis in both.
Analyses of the association of atherosclerosis scores with biologic and
lifestyle characteristics measured at entry into the study indicated that
atherosclerosis in the large arteries was consistently related to age,
diastolic blood pressure, serum cholesterol, and height (inversely). Weak
trends of association were also found with increasing serum glucose
concentration, increasing cigarette use, and decreasing alcohol intake.
Atherosclerosis scores in the small arteries were associated with diastolic
blood pressure and serum triglyceride concentration. Analysis of dietary
intake indicated that atherosclerosis scores were higher for men who
reported low intakes of fat and animal protein and high intakes of
vegetable protein and total carbohydrates. These patterns were consistent
with similar findings on the incidence of clinical stroke in this cohort.
Age- adjusted and -specific atherosclerosis scores from both the large and
small arteries declined significantly during the period 1965-1983.
ARTICLES
A prospective study of cerebral artery atherosclerosis
Honolulu Heart Program, Kuakini Medical Center, Hawaii 96817.
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