Stroke, Vol 19, 892-897, Copyright © 1988 by American Heart Association
K Hongo, T Nakagomi, NF Kassell, T Sasaki, M Lehman, DG Vollmer, T Tsukahara, H Ogawa and J Torner
We evaluated the effects of aging and hypertension on endothelium-
dependent relaxation of rat common carotid arteries using 14-week-old
(young) and 11-month-old (old) Wistar-Kyoto rats (WKY) and age-matched
spontaneously hypertensive rats (SHR). Isometric tension of common carotid
artery ring segments was measured. With a resting tension of 2.0 g
determined from the baseline tension-contraction curves, precontraction was
induced by 10(-5) M 5-hydroxytryptamine and endothelium-dependent
relaxation was measured by application of either acetylcholine or adenosine
5'-triphosphate (ATP). Mean arterial blood pressure was 73.1 +/- 3.0 mm Hg
in WKY and 110.0 +/- 3.1 mm Hg in SHR. These baseline values were
significantly different. Acetylcholine- induced maximal relaxations were
70.1 +/- 2.6% of the 5- hydroxytryptamine-induced contraction in young WKY,
45.6 +/- 2.1% in old WKY, 35.1 +/- 1.8% in young SHR, and 21.4 +/- 2.5% in
old SHR. On the other hand, ATP-induced relaxations were 52.0 +/- 3.2%,
35.7 +/- 3.8%, 21.7 +/- 3.5%, and 17.0 +/- 1.8% in the groups,
respectively. Acetylcholine-induced relaxations were significantly
different between WKY and SHR, young and old, independently. On the other
hand, ATP- induced relaxations were also significantly different between
young and old WKY, although no significant difference was observed between
young and old SHR. The fact that endothelium-dependent relaxation of a
cephalic artery is impaired in old rats and in hypertensive rats suggests
that aging and hypertension are risk factors that may augment the
disturbance of the cerebral circulation in pathologic conditions.
ARTICLES
Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery
Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville 22908.
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