Stroke, Vol 19, 898-902, Copyright © 1988 by American Heart Association
JL Haining, BR Clower, Y Honma and RR Smith
From 2 hours to 23 days following experimental subarachnoid hemorrhage, the
accumulation of indium-111-labeled platelets on the intimal surface of the
middle cerebral artery was studied in 23 cats. Subarachnoid hemorrhage was
produced by transorbital rupture of the right middle cerebral artery. Of
the 23 cats, 17 exhibited right middle cerebral artery/left middle cerebral
artery radioactivity ratios of greater than 1.25. When these results were
compared with those of 12 control cats, 0.001 less than p less than 0.005
(chi2 test). Thus, the results from the control and experimental groups are
significantly different and indicate early (after 2 hours) preferential
accumulation of intimal platelets in the ruptured right middle cerebral
artery compared with the unruptured left middle cerebral artery and new
platelet deposition continuing for up to 23 days. However, the experimental
group did not reveal a clear pattern for platelet accumulation following
subarachnoid hemorrhage. There was no simple correlation between the
magnitude of the radioactivity ratios and the time after hemorrhage when
the cats were killed although the ratios for 2 hours to 7 days seemed
greater than those for 8 to 23 days. Assuming the pivotal role of platelets
in the angiopathy of subarachnoid hemorrhage, the administration of
antiplatelet agents as soon as possible following its occurrence may be of
value.
ARTICLES
Accumulation of intimal platelets in cerebral arteries following experimental subarachnoid hemorrhage in cats
Basic Science Research Laboratory, Veterans Administration Medical Center, Jackson, Mississippi.