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(Stroke. 1971;2:23.)
© 1971 American Heart Association, Inc.

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The Role of the Sympathetic Nervous System in Lipid Deposition. I. Increased Lipid Deposits in the Iris of the Sympathectomized Eye in Rabbits Fed an Atherogenic Diet

JAMES AUSTIN M.D.¹; WILLIAM ROBERTS M.D.¹; HANS NEVILLE M.D.¹; DONALD ARMSTRONG M.S.¹

¹ The Division of Neurology, University of Colorado Medical Center, Denver, Colorado, 80220

Rabbits on a high-cholesterol diet deposit more lipid in the iris of the sympathectomized eye.

Histologically, the lipid deposits are composed of sudanophilic staining droplets localized both in smooth muscle cell cytoplasm of the iris dilator muscle and in larger oval cells. Possible metabolic and vascular mechanisms are noted which may underlie these findings. Potential clinical implications of these findings are cited.

Key Words: experimental atherosclerosis • smooth muscle cells • sudanophilic droplets