This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by FUJISHIMA, M. Articles by REINMUTH, O. M. Search for Related Content PubMed PubMed Citation Articles by FUJISHIMA, M. Articles by REINMUTH, O. M.

(Stroke. 1971;2:251.)
© 1971 American Heart Association, Inc.

---

The Relation Between Cerebral Oxygen Consumption and Cerebral Vascular Reactivity to Carbon Dioxide

MASATOSHI FUJISHIMA M.D.¹; PERITZ SCHEINBERG M.D.²; RAUL BUSTO B.S.²; OSCAR M. REINMUTH M.D.²

¹ Department of Neurology, University of Miami School of Medicine, Miami, Florida, 33152; Second Department of Internal Medicine, Kyushu University School of Medicine, Fukuoka, Japan
² Department of Neurology, University of Miami School of Medicine, Miami, Florida, 33152

The mechanisms whereby CO₂ affects cerebral vessels are not as simple as once thought,^{1, 2} and are probably both directly on cerebral vascular walls^{3, 4} and indirectly by action on brain stem neurones.⁵ Furthermore, cerebral vascular reactivity to CO₂ has been reported to be altered by a number of physiological and pathological circumstances. The capacity to dilate to increased Pa_COCO2 is decreased in cerebral vascular lesions,^6-8 and is affected by changes in cerebral perfusion pressure.⁹ Cervical sympathectomy is said to increase CBF response to Pa_COCO2 changes, whereas sympathetic nerve stimulation abolishes reactivity to CO₂.¹⁰ Deep anesthesia, hypothermia, or trauma to brain reduces reactivity to cerebral vessels to CO₂, the one common denominator for these states being reduced cerebral metabolism. This report demonstrates that the capacity of cerebral vessels to dilate or constrict in response to changes in Pa_COCO2 is influenced by cerebral oxygen consumption.

Key Words: brain stem neurones • autonomic pathways • cerebral anaerobic metabolism • I¹⁸¹ iodo-antipyrine • senile dementia • cerebral seizures

This article has been cited by other articles:

				H. Sugimori, S. Ibayashi, K. Fujii, S. Sadoshima, Y. Kuwabara, and M. Fujishima Can Transcranial Doppler Really Detect Reduced Cerebral Perfusion States? Stroke, November 1, 1995; 26(11): 2053 - 2060. [Abstract] [Full Text]

				W. Cheng, J. F. Hartmann, D. E. Cameron, E. M. Griffiths, J. R. Kirsch, and R. J. Traystman Cerebral Blood Flow During Cardiopulmonary Bypass: Influence of Temperature and pH Management Strategy Ann. Thorac. Surg., April 1, 1995; 59(4): 880 - 886. [Abstract] [Full Text]

				M. Yamamoto, J. S. Meyer, F. Sakai, and F. Yamaguchi Aging and Cerebral Vasodilator Responses to Hypercarbia: Responses in Normal Aging and in Persons With Risk Factors for Stroke Arch Neurol, August 1, 1980; 37(8): 489 - 496. [Abstract] [PDF]