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(Stroke. 1971;2:555.)
© 1971 American Heart Association, Inc.

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Antifibrinolytic Activity During Administration of Epsilon-Aminocaproic Acid

DONALD W. NIBBELINK M.D.¹

¹ Department of Neurology, University of Iowa, University Hospitals, Iowa City, Iowa, 52240

Utilizing an in vitro method for activated and nonactivated whole blood clotlysis determinations, the antifibrinolytic effect of epsilon-aminocaproic acid therapy was evaluated. Initially, the induced antifibrinolytic activity diminished within two hours after the previous dose. Continuing therapy for three to six days resulted in sustained fibrinolytic inhibition.

Key Words: antifibrinolysis • cerebral aneurysm • clot-lysis determination • streptokinase

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