Stroke, Vol 20, 1627-1642, Copyright © 1989 by American Heart Association
MD Ginsberg and R Busto
The use of physiologically regulated, reproducible animal models is crucial
to the study of ischemic brain injury--both the mechanisms governing its
occurrence and potential therapeutic strategies. Several laboratory rodent
species (notably rats and gerbils), which are readily available at
relatively low cost, are highly suitable for the investigation of cerebral
ischemia and have been widely employed for this purpose. We critically
examine and summarize several rodent models of transient global ischemia,
resulting in selective neuronal injury within vulnerable brain regions, and
focal ischemia, typically giving rise to localized brain infarction. We
explore the utility of individual models and emphasize the necessity for
meticulous experimental control of those variables that modulate the
severity of ischemic brain injury.
ARTICLES
Rodent models of cerebral ischemia
Department of Neurology, University of Miami School of Medicine, FL 33101.
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