This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by De Riu, P. L. Articles by Madeddu, G. Search for Related Content PubMed PubMed Citation Articles by De Riu, P. L. Articles by Madeddu, G.

Stroke, Vol 20, 253-258, Copyright © 1989 by American Heart Association

ARTICLES

Beta-endorphin in experimental canine spinal ischemia

PL De Riu, V Petruzzi, G Palmieri, C Gentili, F Melis, MA Caria, GB Azzena, AR Casu, G Marras and G Madeddu
Department of Neurological Rehabilitation, University of Turin, Italy.

Plasma and cerebrospinal fluid beta-endorphin concentrations were radioimmunologically assayed in dogs subjected to spinal cord ischemia induced by infrarenal aortic ligature and in control sham-operated dogs. Plasma beta-endorphin levels rose significantly following surgery in control dogs but were unaffected by spinal ischemia. On the other hand, a significant increase in cerebrospinal fluid beta-endorphin concentration occurred after spinal ischemia, while surgical stress had no significant effect. Thus, the origins of plasma and cerebrospinal fluid beta-endorphin may be different, with the former secreted from the hypophysis and the latter from nervous tissue. Observed changes in cerebrospinal fluid beta-endorphin concentration could be related to the ischemic lesion of nervous tissue while the changes in plasma levels may reflect general stressing factors such as the surgery in our experiments.

This article has been cited by other articles:

				Y. Fujisawa, K. Morishita, J. Fukada, N. Kawaharada, Y. Hachiro, and T. Abe Treatment Methods for Spinal Cord Injury Caused by Acute Type B Aortic Dissection Asian Cardiovasc Thorac Ann, December 1, 2006; 14(6): e106 - e107. [Abstract] [Full Text] [PDF]

				M. Kakinohana, S. Nakamura, T. Fuchigami, K. J. Davison, M. Marsala, and K. Sugahara Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats Br. J. Anaesth., January 1, 2006; 96(1): 88 - 94. [Abstract] [Full Text] [PDF]

				M. Kakinohana, T. Fuchigami, S. Nakamura, T. Sasara, T. Kawabata, and K. Sugahara Intrathecal Administration of Morphine, but Not Small Dose, Induced Spastic Paraparesis After a Noninjurious Interval of Aortic Occlusion in Rats Anesth. Analg., March 1, 2003; 96(3): 769 - 775. [Abstract] [Full Text] [PDF]