Stroke, Vol 20, 333-339, Copyright © 1989 by American Heart Association
MS Dennis, JM Bamford, PA Sandercock and CP Warlow
The Oxfordshire Community Stroke Project is a prospective register of all
new cases of stroke and transient ischemic attack (TIA) in a population of
105,000 residents of Oxfordshire, England. Between November 1, 1981, and
October 31, 1986, 184 patients presented for the first time to a general
practitioner or hospital with a TIA. The crude annual incidence rate was
0.35/1000, 0.42/1000 standardized to the 1981 population of England and
Wales. We estimate that each year approximately 21,000 patients in England
and Wales (about half of whom are greater than 70 years old) consult a
doctor for the first time with a TIA. Approximately 80% of our 184 patients
had TIAs in the carotid distribution; the remainder had TIAs in the
vertebrobasilar distribution or TIAs of uncertain vascular distribution.
The incidence of TIA increased sharply with increasing age, and the overall
incidence in men was very similar to that in women (incidence ratio 1.3).
However, in middle age, men were much more likely to suffer a TIA than
women (odds ratio 2.6), which probably explains the marked male
predominance in most hospital-based studies and treatment trials in which
the elderly, and thus women, are underrepresented. This has important
implications for the design and interpretation of clinical trials of
treatment for TIAs.
ARTICLES
Incidence of transient ischemic attacks in Oxfordshire, England
University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, England.
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