Stroke, Vol 20, 604-608, Copyright © 1989 by American Heart Association
WJ Oczkowski, VC Hachinski, J Bogousslavsky, HJ Barnett and SG Carruthers
A double-blind, randomized, pilot trial of the calcium channel antagonist
PY108-068 was completed in patients with acute ischemic cerebral
infarction. Nine treated patients received PY108-068 orally (150 mg/day in
divided doses) and 10 control patients received placebo within 48 hours of
stroke onset for 21 days. The mean age of the treated patients (four men,
five women) was 63.7 years and of the control patients (seven men, three
women) 64.4 years. Most infarctions were in the territory of the middle
cerebral artery. One treated patient died of sudden cardiac death on Day
12; one control patient died of cerebral herniation. Two treated patients
had episodes of clinically insignificant hypotension during Day 1 of
treatment. Two control patients had myocardial infarctions during the
trial. The mean Toronto Stroke Scale scores at stroke onset were 67 and 90
and at Week 12 were 22.5 and 34.7 in the treated and control groups,
respectively. There was parallel improvement in the two groups, with no
significant difference between groups (p = 0.12). The mean Barthel Index
functional scores at stroke onset were 32.8 and 33 and at Week 12 were 90
and 78.8 in the treated and control groups, respectively. There was a trend
in favor of the treated group, but differences between groups did not reach
significance. In this pilot trial, PY108-068 was found to be safe but not
effective in patients with acute ischemic cerebral infarction.
ARTICLES
A double-blind, randomized trial of PY108-068 in acute ischemic cerebral infarction
Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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