Stroke, Vol 20, 853-857, Copyright © 1989 by American Heart Association
S Ricci, MG Celani, G Guercini, P Rucireta, R Vitali, F La Rosa, E Duca, R Ferraguzzi, M Paolotti and D Seppoloni
The SEPIVAC study (Italian initials for "epidemiologic study of incidence
of acute cerebrovascular disease") is a community-based epidemiologic
survey of incidence and outcome of cerebrovascular disease in the territory
of the 6th Local Health Unit, Umbria, Italy, where 49,101 people live. All
cases were registered with the study either by notification from general
practitioners or by check of hospital admission within the study area and
in the two hospitals of Perugia. Death certificates were looked at as well.
Patients were registered with the study when the clinical picture fulfilled
the definition of stroke and transient ischemic attack (TIA) adopted for
this study. Patients were followed up at approximately 30 days and 6
months. During the first year of the study (September 1, 1986 to August 31,
1987), 189 cases were registered: 108 suffered a "first ever in a lifetime"
stroke, 30 a recurrent stroke, and 51 a "first ever in a lifetime"
transient ischemic attack. Sixty-one percent of patients (71% of first
strokes) had a computed tomography scan. For our study, the crude annual
incidence rate of first stroke was 2.2 per 1,000 (confidence intervals
1.81-2.66); the standardized rate to the European population was 1.36
(confidence intervals 1.06-1.74). At least 83% of first strokes were due to
cerebral ischemia; in 26 cases a clinical diagnosis of lacunar ischemia was
made. The 30-day case fatality rate was 21%; 25% of our patients had
recovered completely or almost completely after 1 month.
ARTICLES
First-year results of a community-based study of stroke incidence in Umbria, Italy
Clinica Neurologica, Perugia, Italy.
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