Stroke, Vol 20, 871-875, Copyright © 1989 by American Heart Association
T Brott, JR Marler, CP Olinger, HP Adams Jr, T Tomsick, WG Barsan, J Biller, R Eberle, V Hertzberg and M Walker
As part of a prospective therapy study of 65 patients with acute,
nonhemorrhagic, cerebral infarction, computed tomographic scans of the head
were obtained at admission, 7-10 days, and 3 months. The scans were
analyzed for the presence, site, size, and volume measurement of the
infarction. At 7-10 days, the mean infarction volume as measured by
computed tomography was 55 cm3 or about 4 x 4 x 3.5 cm (range = 0-507 cm3).
At 3 months, the mean infarction volume decreased by 25% to 41 cm3. For the
26 scans showing infarction at the time of admission, the mean lesion
volume was 33 cm3 at admission, 51 cm3 at 7-10 days, and 49 cm3 at 3
months. With lesion size at 7-10 days expressed as percentage of total
brain volume, the mean infarction size was only 5%. Of the 49 patients with
lesions revealed by computed tomography at 7-10 days, 20 had an infarction
of 1% or less of total brain volume, while only six had an infarction of
20% or more of total brain volume. The lesion volumes as measured by the
7-10-day computed tomography correlated with the neurologic examination
scores on admission (Spearman's rank-order correlation = 0.78) and with the
scores at 1 week (Spearman's rank- order correlation = 0.79).
ARTICLES
Measurements of acute cerebral infarction: lesion size by computed tomography
Department of Neurology, University of Cincinnati, OH.
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