Stroke, Vol 20, 904-910, Copyright © 1989 by American Heart Association
R Busto, MY Globus, WD Dietrich, E Martinez, I Valdes and MD Ginsberg
We have demonstrated previously that mild intraischemic hypothermia confers
a marked protective effect on the final histopathological outcome. The
present study was carried out to evaluate whether this protective effect
involves changes in the degree of local cerebral blood flow reductions,
tissue accumulation of free fatty acids, or alterations in the
extracellular release of glutamate and dopamine. Rats whose intraischemic
brain temperature was maintained at 36 degrees C, 33 degrees C, or 30
degrees C were subjected to 20 minutes of ischemia by four-vessel occlusion
combined with systemic hypotension. Levels of local cerebral blood flow, as
measured autoradiographically, were reduced uniformly in all experimental
animals at the end of ischemia by gas chromatography after tissue
extraction and separation by thin layer chromatography. A massive
ischemia-induced accumulation of individual free fatty acids was observed
in animal groups whose intraischemic brain temperature was maintained at
either 36 degrees C or 30 degrees C. Extracellular neurotransmitter levels
were measured by microdialysis; the perfusate was collected before, during,
and after ischemia. In rats whose intraischemic brain temperature was
maintained at 36 degrees C, dopamine and glutamate increased significantly
during ischemia and the early period of recirculation (by 500-fold and
sevenfold, respectively). In animals whose brain temperature was maintained
at 33 degrees C and 30 degrees C, the release of glutamate was completely
inhibited, and the release of dopamine was significantly attenuated (by
60%). These results suggest that mild intraischemic hypothermia does not
affect the ischemia-induced local cerebral blood flow reduction or free
fatty acid accumulation.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain
Department of Neurology, University of Miami School of Medicine, FL 33101.
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