Stroke, Vol 20, 1000-1004, Copyright © 1989 by American Heart Association
KM Flegel and J Hanley
Factors associated with stroke and other cardiac embolic events in subjects
with nonrheumatic atrial fibrillation were examined in a retrospective
study of 91 patients from a teaching hospital clinic. There were 28 first
strokes during 355 person-years of follow-up (7.9 per 100 person-years).
Patients who had experienced one or more previous events were approximately
2.3 times more likely to have a subsequent event (hazard ratio 2.3, 95%
confidence interval 1.5-3.4) than patients who had experienced no events. A
univariate analysis of factors associated with a first stroke of any cause
or other embolic event showed that age of greater than 75 years (hazard
ratio 2.5) and systolic blood pressure of greater than 160 mm Hg (hazard
ratio 6.4) were significant factors. After adjusting for the effect of age
and systolic blood pressure, previous events still carried an increased
risk for subsequent events. Subject with nonrheumatic atrial fibrillation
who have had one or more embolic events are at high risk of further emboli.
They require special consideration when treatment is being planned.
ARTICLES
Risk factors for stroke and other embolic events in patients with nonrheumatic atrial fibrillation
Department of Medicine, McGill University, Montreal, Canada.
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