Stroke, Vol 20, 1212-1218, Copyright © 1989 by American Heart Association
JS Smeda
The purpose of my study was to assess a North American, Japanese-style diet
commercially available from Zeigler Brothers (Gardners, Pennsylvania) with
respect to the initiation of stroke development in 34 stroke-prone
spontaneously hypertensive rats (spSHR) and in 14 stroke-resistant
spontaneously hypertensive rats (srSHR). Nineteen spSHR fed the diet
containing 4% NaCl and 0.75% K+ (low-K+ diet) from weaning had an
accelerated rate of stroke development (mean +/- SEM age at death 15.3 +/-
0.5 weeks). The same diet containing 2.11% K+ (high- K+ diet) increased the
mean lifespan of 15 spSHR by 39% but did not prevent stroke. The locations
of hemorrhagic lesions were similar in the groups of spSHR fed high- and
low-K+ diets, being nearly equally divided between the territories of the
anterior, posterior, and middle cerebral arteries. The 14 srSHR fed the
low-K+ diet exhibited 50% mortality at 66 weeks of age. However, in the
srSHR fed the low-K+ diet, death did not result from hemorrhagic stroke.
The differing incidence of stroke between the spSHR fed high- and low-K+
diets and between spSHR and srSHR fed the low-K+ diet could not be
explained on the basis of differing blood pressures. Compared with spSHR
fed the low- K+ diet, both srSHR fed the low-K+ diet and spSHR fed the
high-K+ diet exhibited higher drinking and urine excretion rates and
elevated plasma K+ levels. My study indicates the availability of a
commercial North American diet that produces a predictable high incidence
of stroke within a compressed time period in spSHR but not in srSHR. This
diet would be useful in studies attempting to determine the events
preceding and leading to the development of stroke and in determining the
genetic factors responsible for stroke resistance.
ARTICLES
Hemorrhagic stroke development in spontaneously hypertensive rats fed a North American, Japanese-style diet
Department of Anaesthesia, McMaster University, Hamilton, Canada.
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