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Stroke, Vol 21, 138-140, Copyright © 1990 by American Heart Association

ARTICLES

Baclofen does not protect against cerebral ischemia in rats

DM Rosenbaum, JC Grotta, LC Pettigrew, P Ostrow, R Strong, H Rhoades, CM Picone and AT Grotta
Department of Neurology, University of Texas Health Science Center, Houston 77030.

Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats. Baclofen (10 mg/kg i.p.) given 1 hour before and 30-60 minutes after 20 minutes of global ischemia did not lessen mortality, prevent ischemic cellular damage, or significantly improve working memory compared with no treatment. We conclude that preischemic and postischemic administration of baclofen does not protect neurons from ischemic injury.

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