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Stroke, Vol 21, 1419-1423, Copyright © 1990 by American Heart Association
D Inzitari, GP Giordano, AL Ancona, G Pracucci, M Mascalchi and L Amaducci
To investigate whether the observed association of leukoaraiosis with
intracerebral hemorrhage is direct or mediated by risk factors, we compared
116 patients with intracerebral hemorrhage confirmed by computed tomography
and 155 controls without intracerebral hemorrhage, evaluating the
prevalence of leukoaraiosis and vascular risk factors. Leukoaraiosis was
observed in 21 (18%) of the 116 patients and in 12 (8%) of the 155 controls
(p less than 0.01). Only two (6%) of the 31 patients with lobar hemorrhage
had leukoaraiosis on computed tomograms, compared with 17 (24%) of the 71
patients with basal ganglionic hemorrhage (p less than 0.05). Leukoaraiosis
was significantly correlated with intracerebral hemorrhage after
controlling for age and sex by using multiple logistic regression analysis,
while the correlation disappeared after controlling for hypertension. Our
results indicate that leukoaraiosis is not an independent risk factor for
intracerebral hemorrhage.
ARTICLES
Leukoaraiosis, intracerebral hemorrhage, and arterial hypertension
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
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