This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Brunetti, A. Articles by Alger, J. R. Search for Related Content PubMed PubMed Citation Articles by Brunetti, A. Articles by Alger, J. R.

Stroke, Vol 21, 1439-1444, Copyright © 1990 by American Heart Association

ARTICLES

Cerebral blood flow in experimental ischemia assessed by 19F magnetic resonance spectroscopy in cats

A Brunetti, G Nagashima, A Bizzi, DJ DesPres and JR Alger
Neuroimaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

We evaluated a 19F magnetic resonance spectroscopic technique that detects Freon-23 washout as a means of measuring cerebral blood flow in halothane-anesthetized adult cats during and after transient cerebral ischemia produced by vascular occlusion. The experiments were performed to test the ability of this recently developed method to detect postischemic flow deficits. Results were consistent with postischemic hypoperfusion. The method also proved valuable for measuring small residual flow during vascular occlusion. Our experiments indicate that this method provides simple, rapid, and repeatable flow measurements that can augment magnetic resonance examinations of cerebral metabolic parameters in the study of ischemia.