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Stroke, Vol 21, 1503-1505, Copyright © 1990 by American Heart Association

ARTICLES

Cerebral venous thrombosis due to heparin-induced thrombocytopenia

AP Kyritsis, EC Williams and HS Schutta
Department of Neurology, University of Wisconsin School of Medicine, Madison.

A patient with polycythemia vera who was treated with heparin for superficial septic thrombophlebitis developed heparin-induced thrombocytopenia and cerebral venous thrombosis with superior sagittal sinus occlusion 11 days after the institution of heparin therapy. We suggest that the severe thrombotic response to the heparin-induced platelet disorder in this patient occurred because the polycythemia vera and the purulent infection enhanced the thrombophilia caused by heparin-induced thrombocytopenia. This condition can be avoided in most instances if heparin is used for no longer than 5 days.

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