Stroke, Vol 21, 1529-1532, Copyright © 1990 by American Heart Association
R Monforte, R Estruch, F Graus, JM Nicolas and A Urbano-Marquez
We examined the prevalence of high ethanol intake, hypertension, and other
risk factors for intracerebral hemorrhage in a case-control study of 24
young and middle-aged patients with intracerebral hemorrhage. We recorded
ethanol consumption, history of hypertension, liver disease, cigarette
smoking, and mild or severe coagulation disorder in each case of
intracerebral hemorrhage and in 48 control patients matched by sex and age.
In univariate matched analyses, the frequencies of high ethanol intake (p =
0.009), hypertension (p = 0.05), and coagulation disorder (p = 0.05) were
higher in the cases than in the controls. After controlling for possible
confounding factors, we found that high ethanol intake and hypertension
were the only independent risk factors for intracerebral hemorrhage (p =
0.02 and p = 0.05, respectively). The hemorrhagic lesion found in cases
with a high ethanol intake tended to be located in the cerebral lobes (p =
0.01), contrasting with the typical basal ganglia location of hypertensive
hematomas (p = 0.009). We conclude that chronic, high ethanol intake should
be considered as an important risk factor for lobar hematomas in young and
middle-aged people.
ARTICLES
High ethanol consumption as risk factor for intracerebral hemorrhage in young and middle-aged people
Department of Internal Medicine, Hospital Clinic i Provincial, Barcelona, Spain.
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