Stroke, Vol 21, 223-229, Copyright © 1990 by American Heart Association
P Harmsen, A Rosengren, A Tsipogianni and L Wilhelmsen
To evaluate stroke risk factors in Goteborg, Sweden, during 1970-1973 a
cohort of 7,495 participating men from a general population sample of 9,998
men aged 47-55 years were examined with respect to cardiovascular risk
factors. Men with hypertension and hypercholesterolemia and men who were
heavy smokers were treated. We assessed stroke end points and
cause-specific mortality using a stroke register and death certificates.
During a mean follow-up of 11.8 years, 230 strokes occurred in the entire
population sample (participants and nonparticipants) (7% subarachnoid
hemorrhages, 13% intracerebral hemorrhages, 42% cerebral infarctions, and
38% unspecified strokes). Using univariate analysis, we found measured high
blood pressure (systolic and diastolic), smoking, known hypertension,
diabetes mellitus, stroke in either parent, severe psychological stress,
marital status, atrial fibrillation, previous transient ischemic attacks,
previous myocardial infarction, effort-induced chest pain, and intermittent
claudication to be significantly related to all stroke. Of the stroke
types, subarachnoid hemorrhage was not related to any of these indicators,
and intracerebral hemorrhage was related only to measured high blood
pressure. Using multivariate analyses, we found measured high blood
pressure, smoking, and severe psychological stress as well as atrial
fibrillation, previous transient ischemic attacks, and intermittent
claudication to be independent risk factors for nonhemorrhagic stroke.
Serum cholesterol concentration, occupational and leisure-time physical
activity, body mass index, alcohol abuse, and low occupational class were
not risk factors for stroke.
ARTICLES
Risk factors for stroke in middle-aged men in Goteborg, Sweden
Department of Neurology, Ostra Hospital, Gothenburg University, Sweden.
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|
|
|
|
|
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