This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fisher, M. Articles by Fieman, S. Search for Related Content PubMed PubMed Citation Articles by Fisher, M. Articles by Fieman, S. Pubmed/NCBI databases Medline Plus Health Information Carotid Artery Disease

Stroke, Vol 21, 267-271, Copyright © 1990 by American Heart Association

ARTICLES

Geometric factors of the bifurcation in carotid atherogenesis

M Fisher and S Fieman
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.

In vitro studies have demonstrated that geometry of the carotid bifurcation predicts blood flow alterations associated with atherosclerotic plaque formation. We investigated intraindividual asymmetry of carotid atherosclerosis by measuring geometric aspects of the carotid bifurcation. We measured diameter stenosis, the internal carotid artery/common carotid artery area ratio, and the angle of the carotid bifurcation on 40 arteriograms. Stenosis asymmetry was significantly associated with area ratio asymmetry (r = 0.355, p less than 0.025); there was no such association between stenosis asymmetry and bifurcation angle asymmetry. Geometric factors of the carotid bifurcation, particularly the area ratio, may help explain intraindividual asymmetry in carotid atherosclerosis.

This article has been cited by other articles:

				S.-W. Lee, L. Antiga, J. D. Spence, and D. A. Steinman Geometry of the Carotid Bifurcation Predicts Its Exposure to Disturbed Flow Stroke, August 1, 2008; 39(8): 2341 - 2347. [Abstract] [Full Text] [PDF]

				J. B. Thomas, L. Antiga, S. L. Che, J. S. Milner, D. A. Hangan Steinman, J. D. Spence, B. K. Rutt, and D. A. Steinman Variation in the Carotid Bifurcation Geometry of Young Versus Older Adults: Implications for Geometric Risk of Atherosclerosis Stroke, November 1, 2005; 36(11): 2450 - 2456. [Abstract] [Full Text] [PDF]

				R. Ceravolo, R. Maio, A. Pujia, A. Sciacqua, G. Ventura, M. C. Costa, G. Sesti, and F. Perticone Pulse pressure and endothelial dysfunction in never-treated hypertensive patients J. Am. Coll. Cardiol., May 21, 2003; 41(10): 1753 - 1758. [Abstract] [Full Text] [PDF]

				M. Sitzer, D. Puac, A. Buehler, D. A. Steckel, S. von Kegler, H. S. Markus, and H. Steinmetz Internal Carotid Artery Angle of Origin: A Novel Risk Factor for Early Carotid Atherosclerosis Stroke, April 1, 2003; 34(4): 950 - 955. [Abstract] [Full Text] [PDF]

				U. G.R. Schulz and P. M. Rothwell Major Variation in Carotid Bifurcation Anatomy: A Possible Risk Factor for Plaque Development? Stroke, November 1, 2001; 32(11): 2522 - 2529. [Abstract] [Full Text] [PDF]

				U. G.R. Schulz and P. M. Rothwell Sex Differences in Carotid Bifurcation Anatomy and the Distribution of Atherosclerotic Plaque Stroke, July 1, 2001; 32(7): 1525 - 1531. [Abstract] [Full Text] [PDF]

				J. Ravensbergen, J. W. Ravensbergen, J. K. B. Krijger, B. Hillen, and H. W. Hoogstraten Localizing Role of Hemodynamics in Atherosclerosis in Several Human Vertebrobasilar Junction Geometries Arterioscler. Thromb. Vasc. Biol., May 1, 1998; 18(5): 708 - 716. [Abstract] [Full Text] [PDF]

				G. J. Hademenos and T. F. Massoud Biophysical Mechanisms of Stroke Stroke, October 1, 1997; 28(10): 2067 - 2077. [Abstract] [Full Text]

				A. Gnasso, C. Carallo, C. Irace, V. Spagnuolo, G. De Novara, P. L. Mattioli, and A. Pujia Association Between Intima-Media Thickness and Wall Shear Stress in Common Carotid Arteries in Healthy Male Subjects Circulation, December 15, 1996; 94(12): 3257 - 3262. [Abstract] [Full Text]