Stroke, Vol 21, 731-739, Copyright © 1990 by American Heart Association
SL Wood-Dauphinee, JI Williams and SH Shapiro
We investigated the relation between outcome and sample size for six
selected stroke outcome measures to assist investigators in selecting end
points for stroke studies. Data from a clinical trial of 167 stroke
patients assessed shortly after admission to the hospital and 5 weeks later
provided information on clinical, motor, and functional outcomes measured
using a neurologic status scale, a stroke severity scale, the Fugl-Meyer
Scale, the Barthel Index, and the activities of daily living and cognition
subscales of the Level of Rehabilitation Scale. Data were examined using
Pearson correlation coefficients and power analyses. All measures were
significantly correlated. There was also substantial congruency between the
subscales of a measure and its total score. The measures had variable
efficiencies; the Barthel Index was the most efficient and therefore
required the fewest subjects to identify a significant effect. These data
suggest that careful consideration must be given to the choice of stroke
outcome measures in terms of their numbers, interrelationships, and
statistical properties, as these factors have important implications for
the design, analysis, and conduct of clinical stroke studies.
ARTICLES
Examining outcome measures in a clinical study of stroke
School of Physical and Occupational Therapy, McGill University, Montreal, Canada.
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