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Stroke, Vol 21, 817-819, Copyright © 1990 by American Heart Association

ARTICLES

Cerebral sinus thrombosis as a potential hazard of antifibrinolytic treatment in menorrhagia

A Achiron, M Gornish and E Melamed
Department of Neurology, Beilinson Medical Center, Petach-Tiqva, Israel.

We describe a 42-year-old woman who developed superior sagittal and left transverse sinus thrombosis associated with prolonged epsilon- aminocaproic acid therapy for menorrhagia. This antifibrinolytic agent has been used in women with menorrhagia to promote clotting and reduce blood loss. Although increased risk of thromboembolic disease has been reported during treatment with epsilon-aminocaproic acid, cerebral sinus thrombosis has not been previously described. Careful use of epsilon-aminocaproic acid therapy is recommended.