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Stroke, Vol 21, 890-894, Copyright © 1990 by American Heart Association
A Hijdra, B Verbeeten Jr and JA Verhulst
Nonspecific periventricular white matter lucencies on computed tomograms
(leukoaraiosis) were found in 141 (38%) of 367 patients with ischemic or
hemorrhagic strokes. Patients with leukoaraiosis were significantly older
than those without it and were significantly more likely to have
hypertension, diabetes mellitus, general vascular disease, and lacunar
infarcts on computed tomograms but were less likely to have cortical
infarcts. Because many of these variables may be mutually dependent, we
performed a logistic regression analysis examining all clinical and
computed tomographic variables. The analysis demonstrated that increasing
age, lacunar infarcts, and hemorrhages were significant determinants of
leukoaraiosis; cortical infarcts were also significantly, but negatively,
correlated with leukoaraiosis. In patients with hemorrhages, leukoaraiosis
occurred significantly more often when aneurysms or arteriovenous
malformations were not demonstrated. These findings suggest that in
patients with cerebrovascular disorders leukoaraiosis is associated with
small-vessel disease.
ARTICLES
Relation of leukoaraiosis to lesion type in stroke patients
Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands.
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