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Stroke, Vol 21, 895-900, Copyright © 1990 by American Heart Association
F Giubilei, GL Lenzi, V Di Piero, C Pozzilli, P Pantano, S Bastianello, C Argentino and C Fieschi
We investigated 32 patients with completed ischemic stroke less than or
equal to 6 hours after the onset of symptoms by means of computed
tomography, cerebral angiography, and technetium-99m-labeled
hexamethylpropyleneamine oxime single-photon emission computed tomography
to study cerebral blood flow. Follow-up computed tomography and cerebral
blood flow studies were performed 1 week and 1 month after admission. Poor
outcome at 1 month was evident in 18 (78%) of the 23 patients with severe
neurologic deficit on admission and in 11 (92%) of the 12 patients with
severe hypoperfusion in the affected hemisphere on admission. All 10
patients with severe impairment of both neurologic status and cerebral
blood flow had a poor outcome at 1 month. We detected severe hypoperfusion
in patients with large lesions on computed tomograms or cerebral artery
occlusions on angiograms. Cerebral blood flow had increased at the 1-week
follow-up despite different clinical outcomes. Our data provide evidence
that early evaluation of cerebral blood flow with single-photon emission
computed tomography is useful to detect subgroups of patients with
different clinical outcomes during the acute phase of ischemic stroke.
ARTICLES
Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke
Department of Neurological Sciences, University of Rome La Sapienza, Italy.
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