This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Scavini, C. Articles by Racagni, G. Search for Related Content PubMed PubMed Citation Articles by Scavini, C. Articles by Racagni, G.

Stroke, Vol 21, 943-947, Copyright © 1990 by American Heart Association

ARTICLES

Kappa-opioid receptor changes and neurophysiological alterations during cerebral ischemia in rabbits

C Scavini, A Rozza, P Bo, E Lanza, L Favalli, F Savoldi and G Racagni
Institute of Pharmacology and Neurologic Institute C. Mondino, University of Pavia, Italy.

Endogenous opioids have been shown to produce beneficial effects in experimental stroke. To evaluate both neurophysiological and biochemical parameters, we induced massive cerebral ischemia in 11 rabbits according to the method standardized in our laboratory, using microspheres injected through the internal carotid artery. Binding studies were performed in the 11 embolized, in nine control, and in five sham-operated rabbits using the appropriate concentration of [3H]dynorphin A (1-8). Neurophysiological parameters were evaluated under baseline conditions and 1 hour after embolization, surgical preparation, or sham operation in 17 rabbits. Comparison of visual readings of the electroencephalograms and analyses of the quantified electroencephalograms under baseline conditions and after embolization indicated a marked and statistically significant (p less than 0.01) increase in bilateral delta activity; histologic examination confirmed bilateral brain edema. Binding studies on kappa-opioid receptors indicate that 1 hour after embolization there were significantly more (28%) kappa-opioid receptors (Bmax) in six embolized rabbits than in five sham-operated animals. No significant changes were observed in the affinity parameters, particularly in the dissociation constant (Kd). Our results indicate a role for endogenous dynorphin peptides in the pathogenesis of stroke.

This article has been cited by other articles:

				B. Yulug, E. Cam, A. Yildiz, and E. Kilic Buprenorphine Does Not Aggrevate Ischemic Neuronal Injury in Experimental Focal Cerebral Ischemia J Neuropsychiatry Clin Neurosci, August 1, 2007; 19(3): 331 - 334. [Abstract] [Full Text] [PDF]

				W. M. Clark, E. C. Raps, D. C. Tong, and R. E. Kelly Cervene (Nalmefene) in Acute Ischemic Stroke : Final Results of a Phase III Efficacy Study Stroke, June 1, 2000; 31(6): 1234 - 1239. [Abstract] [Full Text] [PDF]