This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johshita, H. Articles by Sasaki, T. Search for Related Content PubMed PubMed Citation Articles by Johshita, H. Articles by Sasaki, T.

Stroke, Vol 21, 1051-1058, Copyright © 1990 by American Heart Association

ARTICLES

Blood-brain barrier disturbance following subarachnoid hemorrhage in rabbits

H Johshita, NF Kassell and T Sasaki
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.

We studied disruption of the blood-brain barrier after experimental subarachnoid hemorrhage induced by an injection of 4 ml autologous arterial blood into the cisterna magna of rabbits. The animals were killed at 40 minutes, 6 hours, 1 day, 2 days, 4 days, or 6 days after subarachnoid hemorrhage. We assessed the integrity of the barrier function of intraparenchymal vessels in the ventral brain stem and cerebral hemispheres morphologically with transmission electron microscopy, using horseradish peroxidase as a tracer. In the ventral brain stem, which was in direct contact with the cisternal clots, markedly increased peroxidase staining toward the core of the brain stem was observed on the first day after subarachnoid hemorrhage. In an area of the cerebral hemispheres distant from the clots, barrier disturbance was prominent in the 6-hour specimens, and permeation of the tracer was spotty. From the distribution and morphological findings of these lesions, permeability changes in the ventral brain stem may have been caused by a direct effect of the cisternal clots; in the cerebral hemispheres, hemodynamic factors and changes in intracranial pressure associated with the elderly stages of subarachnoid hemorrhage seemed to be responsible. These results suggest that barrier disturbance associated with subarachnoid hemorrhage may be multifactorial in time course and location.

This article has been cited by other articles:

				T.P. Doczi Impact of Cerebral Microcirculatory Changes on Cerebral Blood Flow During Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage Stroke, March 1, 2001; 32(3): 817 - 817. [Full Text] [PDF]

				M. Bavbek, R. Polin, A.-L. Kwan, A. S. Arthur, N. F. Kassell, K. S. Lee, and R. L. Macdonald Monoclonal Antibodies Against ICAM-1 and CD18 Attenuate Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Rabbits • Editorial Comment Stroke, September 1, 1998; 29(9): 1930 - 1936. [Abstract] [Full Text] [PDF]