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Stroke, Vol 21, 1077-1080, Copyright © 1990 by American Heart Association

ARTICLES

Ischemic stroke due to protein C deficiency

J Kohler, J Kasper, I Witt and GM von Reutern
Department of Neurology, University of Freiburg, Federal Republic of Germany.

Plasma protein C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism. However, arterial thrombosis has been only rarely observed. We describe a young patient with heterozygous protein C deficiency who experienced a severe stroke due to thrombotic occlusion of the left middle cerebral artery.

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