Stroke, Vol 22, 1414-1418, Copyright © 1991 by American Heart Association
H Yao, S Sadoshima, H Ooboshi, Y Sato, H Uchimura and M Fujishima
BACKGROUND AND PURPOSE: We sought to determine the effects of aging on
regional cerebral blood flow and ischemic brain damage in transient
cerebral ischemia in rats. METHODS: Five adult (5-6 months) and five aged
(18-22 months) female spontaneously hypertensive rats were subjected to 20
minutes of bilateral carotid occlusion and 60 minutes of recirculation
under amobarbital anesthesia (100 mg/kg i.p.). Regional cerebral blood flow
in the hippocampus and striatum was measured using the hydrogen clearance
method. Nine adult and 14 aged rats were subjected to 20 minutes of
bilateral carotid occlusion or were sham-operated under ether anesthesia.
Seven days after 20 minutes of cerebral ischemia, the rats' brains were
perfusion fixed. Ischemic damage in the hippocampus and striatum was graded
(0 [normal] to 3 [majority of neurons damaged]). RESULTS: After 20 minutes
of bilateral carotid occlusion, striatal cerebral blood flow decreased to
9.1 +/- 1.5 and 3.9 +/- 2.0 ml/100 g/min in aged and adult rats,
respectively, and hippocampal cerebral blood flow decreased to 8.6 +/- 2.4
and 5.7 +/- 2.4 in aged and adult rats, respectively. Although these
ischemic cerebral blood flow values were not significantly different
between the two age groups, scores for ischemic damage in the hippocampus
CA-1 subfield and striatum were significantly higher in aged than in adult
rats (p less than 0.05, Kruskal-Wallis' h test with Bonferroni correction).
CONCLUSIONS: We conclude that aging may be a primary factor in the
development of greater ischemic neuronal damage observed in aged
hypertensive rats.
ARTICLES
Age-related vulnerability to cerebral ischemia in spontaneously hypertensive rats
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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