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Stroke, Vol 22, 401-405, Copyright © 1991 by American Heart Association

ARTICLES

Cerebral venous thrombosis with plasminogen deficiency

HS Schutta, EC Williams, BG Baranski and TP Sutula
Department of Neurology, University of Wisconsin School of Medicine, Madison.

We describe a patient with inherited plasminogen deficiency who developed extensive cerebral venous thrombosis. Several other conditions that might have contributed to a hypercoagulable state, including mild thrombocytosis, thyrotoxicosis, and a chronic inflammatory lung disorder, were present. We also discuss the evidence linking plasminogen deficiency with a thrombophilic state. The diagnosis of cerebral venous thrombosis in this case was readily established by nuclear magnetic resonance imaging, a technique that is ideally suited for the evaluation and follow-up of patients with this condition.

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