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Stroke, Vol 22, 410-413, Copyright © 1991 by American Heart Association

ARTICLES

Scleroderma and central nervous system vasculitis

R Pathak and AJ Gabor
Department of Neurology, University of California, Davis, Sacramento.

We describe a patient with scleroderma (CREST syndrome) and central nervous system vasculitis. While angiography demonstrated segmental symmetrical arterial narrowing characteristic of vasculitis, results of leptomeningeal biopsy were normal. There was no evidence of systemic vasculitis, renal failure, or malignant hypertension previously thought to be required to explain central nervous system dysfunction in patients with scleroderma. Signs and symptoms attributable to vasculitis were reversible with aggressive immunosuppressive therapy.

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