Stroke, Vol 22, 837-841, Copyright © 1991 by American Heart Association
LM Brass and LA Shaker
To determine the influence of family history on vascular disease, we
surveyed hospital patients discharged with a diagnosis of transient
ischemic attack. Of 117 respondents, 81 knew their family history for
myocardial infarction and 81 knew their family history for stroke. Of 83
responding 43 reported a personal history of myocardial infarction, and of
85 responding 66 reported a personal history of stroke. As expected, there
was an association between positive family and personal histories of
myocardial infarction in younger (aged less than 70 years) patients
(Fisher's two-tailed exact test, p = 0.014). This association was reversed
for stroke (Fisher's two-tailed exact test, p = 0.017). Older (aged greater
than or equal to 70 years) patients had a stronger association between
positive family and personal histories of stroke; 14 (74%) of 19 older
patients with a positive personal history of stroke had a positive family
history of stroke. The reason for this reversal in the relation between
family and personal histories of stroke compared with myocardial infarction
may relate to the older age at onset of most strokes, differing stroke
subtypes in older age groups, or lower rates of fatal myocardial
infarction. This study suggests that familial factors may be important in
some subtypes of cerebrovascular disease. Familial effects may be different
in vascular diseases of the heart and brain.
ARTICLES
Family history in patients with transient ischemic attacks
Department of Neurology, Yale University School of Medicine, New Haven, Conn. 06510.
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