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Stroke, Vol 22, 872-876, Copyright © 1991 by American Heart Association

ARTICLES

Cerebral hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits

WM Clark, KP Madden, PD Lyden and JA Zivin
Department of Neurology, Oregon Health Sciences University, Portland.

We studied the incidence of cerebral hemorrhage in an animal model of embolic stroke to determine the safety of aspirin, heparin, and tissue plasminogen activator therapies. We occluded the middle cerebral arteries of rabbits with labeled blood clots and administered either tissue plasminogen activator, heparin, aspirin, tissue plasminogen activator plus aspirin, tissue plasminogen activator plus heparin, or saline at various times after stroke. Compared to saline controls, both the aspirin-only and the tissue plasminogen activator-plus-aspirin groups had a significantly higher incidence of cerebral hemorrhage, whereas the heparin and tissue plasminogen activator combination groups did not. We conclude that aspirin antiplatelet therapy alone may increase the risk of hemorrhagic infarction, whereas heparin or tissue plasminogen activator therapy appears to be relatively safe.

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