Stroke, Vol 22, 877-883, Copyright © 1991 by American Heart Association
WM Clark, KP Madden, R Rothlein and JA Zivin
Activated leukocytes appear to be directly involved in ischemic central
nervous system injury. A surface glycoprotein (CD18) on the leukocyte is
required for endothelial adherence and subsequent function and can be
blocked with leukocyte adhesion antibody treatment. We used two animal
models to determine the efficacy of anti-CD18 antibody treatment in
preserving neurologic function after central nervous system ischemia. We
gave a dose of 1 mg/kg anti-CD18 to treatment rabbits 30 minutes before
inducing irreversible ischemia in the brain with intraarterial microspheres
or in the spinal cord using reversible aortic occlusion. Treatment with
anti-CD18 produced a significant reduction in neurologic deficits in the
reversible spinal cord model, but not in the irreversible microsphere
model. This protective effect supports the active role of leukocytes in
central nervous system reperfusion ischemic injury and offers potential for
future therapy.
ARTICLES
Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment
Department of Neurology, Oregon Health Sciences University, Portland 97201.
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