This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zubenko, G. S. Articles by Teply, I. Search for Related Content PubMed PubMed Citation Articles by Zubenko, G. S. Articles by Teply, I.

Stroke, Vol 22, 997-1003, Copyright © 1991 by American Heart Association

ARTICLES

Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease

GS Zubenko, RP Brenner and I Teply
Department of Psychiatry, University of Pittsburgh School of Medicine 15213.

We have previously reported that increased platelet membrane fluidity identifies a subgroup of patients with Alzheimer's disease who have distinct clinical features including an earlier age of symptomatic onset, a more rapidly progressive cognitive decline, and a decreased prevalence of focal electroencephalographic findings. In the current study, these patients also exhibited a decreased prevalence of risk factors for stroke compared with patients who had normal platelet membrane fluidity. Our findings suggest that the platelet membrane abnormality describes a clinical subgroup of patients with Alzheimer's disease who are less likely to have coexisting cerebrovascular disease than the remaining patients who meet clinical consensus criteria for probable Alzheimer's disease.

This article has been cited by other articles:

				G. S. Zubenko, E. Winwood, B. Jacobs, I. Teply, J. S. Stiffler, H. B. Hughes III, F. J. Huff, T. Sunderland, and A. J. Martinez Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years Am J Psychiatry, January 1, 1999; 156(1): 50 - 57. [Abstract] [Full Text]