This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fisher, M. Articles by Meiselman, H. J. Search for Related Content PubMed PubMed Citation Articles by Fisher, M. Articles by Meiselman, H. J.

Stroke, Vol 22, 1164-1169, Copyright © 1991 by American Heart Association

ARTICLES

Hemorheological factors in cerebral ischemia

M Fisher and HJ Meiselman
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.

We investigated 100 consecutive cerebral ischemia patients for hemorheological alterations. We measured whole and adjusted blood viscosity at 75 and 1,500 sec-1, plasma viscosity, red blood cell aggregation by the zeta sedimentation ratio, and red blood cell deformability using the centrifugal deformability technique. Patients were studied within 72 hours of the acute ischemic event, and 66 were available for follow-up evaluation approximately 2 months later. Two age- and sex-matched control groups were evaluated: 20 nonvascular neurological inpatients (patient controls) and 45 normal volunteers (normal controls). Compared with normal controls, we found significant acute increases in whole blood viscosity (1,500 sec-1), plasma viscosity, fibrinogen concentration, and zeta sedimentation ratio; the latter two variables were also increased at follow-up. Fibrinogen concentration was significantly associated with zeta sedimentation ratio and plasma viscosity and was increased for patient controls. There was a trend toward normalization of acute abnormalities over the 2-month follow-up period, and patients with more severe strokes tended to have more extensive hemorheological abnormalities. Among patients with severe stroke, fibrinogen concentration was significantly associated with the platelet activation peptide beta-thromboglobulin acutely (r = 0.63, p less than 0.005). We conclude that hemorheological abnormalities in cerebral ischemia are largely nonspecific findings, with the likely exception of patients with severe stroke.

This article has been cited by other articles:

				Y. Aono, T. Ohkubo, M. Kikuya, A. Hara, T. Kondo, T. Obara, H. Metoki, R. Inoue, K. Asayama, Y. Shintani, et al. Plasma Fibrinogen, Ambulatory Blood Pressure, and Silent Cerebrovascular Lesions: The Ohasama Study Arterioscler. Thromb. Vasc. Biol., April 1, 2007; 27(4): 963 - 968. [Abstract] [Full Text] [PDF]

				U. M. Okorie and S. L. Diamond Matrix Protein Microarrays for Spatially and Compositionally Controlled Microspot Thrombosis under Laminar Flow Biophys. J., November 1, 2006; 91(9): 3474 - 3481. [Abstract] [Full Text] [PDF]

				H. Dadgostar, G. N. Holland, X. Huang, A. Tufail, A. Kim, T. C. Fisher, W. G. Cumberland, H. J. Meiselman, A. Benjamin, and D.-U. Bartsch Hemorheologic Abnormalities Associated with HIV Infection: In Vivo Assessment of Retinal Microvascular Blood Flow. Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 3933 - 3938. [Abstract] [Full Text] [PDF]

				A. Chamorro, N. Vila, C. Ascaso, A. Saiz, J. Montalvo, P. Alonso, and E. Tolosa Early Prediction of Stroke Severity : Role of the Erythrocyte Sedimentation Rate Stroke, April 1, 1995; 26(4): 573 - 576. [Abstract] [Full Text]