Stroke, Vol 23, 28-32, Copyright © 1992 by American Heart Association
E Lindenstrom, G Boysen, J Nyboe and M Appleyard
BACKGROUND AND PURPOSE: Temporal trends in stroke incidence in Denmark have
not been previously reported. The Copenhagen City Heart Study is a
prospective study based on a randomly selected sample of an urban
population of, initially, 19,698 participants followed since 1976. Over a
period of 12 years, we studied three important aspects of stroke incidence
in 848 identified cases: temporal trends, dependence on age and sex, and
comparison of responders and nonresponders. METHODS: The participants were
invited to two health examinations at 5-year intervals. The participants
who attended at least one of the two examinations are termed responders and
those who attended none nonresponders. The cases of first-ever stroke were
collected from responders, the National Patient Register, and the National
Register of Deaths and were verified by study of hospital records and death
certificates. RESULTS: For responders aged 35-64 years and greater than or
equal to 65 years, there were no significant changes in the weighted rates
in four consecutive 3-year periods. There was a tendency toward decreasing
rates among younger women, but not in older women or men. The age- and
sex-adjusted rates per 1,000 (based on the Danish population in 1982) in
responders in the entire 12-year follow-up period were 1.61 in women, 2.67
in men, and 2.14 in both sexes combined. Stroke incidence rates increased
exponentially with age in both sexes, with rates in men generally twice
those in women, even in the greater than or equal to 75 years of age group.
Age-adjusted rates were higher in nonresponders than in responders. For
women, this ratio was 1.7; for men, 1.1. CONCLUSIONS: The stroke incidence
in Copenhagen is relatively high and has shown no decreasing tendency over
the period 1976-1988.
ARTICLES
Stroke incidence in Copenhagen, 1976-1988
Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
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