Stroke, Vol 23, 9-14, Copyright © 1992 by American Heart Association
RE Kelley, JY Chang, NJ Scheinman, BE Levin, RC Duncan and SC Lee
BACKGROUND AND PURPOSE: The purpose of this study was to assess the ability
of transcranial Doppler ultrasonography to detect selective circulatory
changes during cognitive activity. METHODS: We measured cerebral artery
flow velocity in 21 normal volunteers by transcranial Doppler
ultrasonography during rest followed by cerebral activation. Mean and peak
systolic flow velocities of the anterior, middle, and posterior cerebral
arteries were measured during the performance of a commercial video game.
We also measured flow velocity of the anterior cerebral arteries in 18
subjects during a mental arithmetic task. Serial measurements of the right
and left sides were made with a headband with two probes. RESULTS: We
observed a global increase in the flow velocity above baseline measurements
during task performance. During the video game, both middle cerebral
arteries (t = 2.6, p = 0.02 for the left; t = 3.3, p = 0.004 for the right)
and the left posterior cerebral artery (t = 2.2, p = 0.004) had selective
increase in mean flow velocity compared with the ipsilateral anterior
cerebral artery. This selective activation was most prominent in the right
middle cerebral artery, which had a greater degree of activation than the
right posterior cerebral artery (t = 2.8, p = 0.013). We did not observe a
statistically significant difference between the right and left middle
cerebral arteries, but there was a trend toward a greater activation on the
right for both the mean velocity (t = 1.7, p = 0.098) and the peak velocity
(t = 1.9, p = 0.079). CONCLUSIONS: Our preliminary investigation suggests
that this noninvasive technique has the potential to correlate selective
cerebral artery flow dynamics with cognitive activity.
ARTICLES
Transcranial Doppler assessment of cerebral flow velocity during cognitive tasks
Department of Neurology, University of Miami School of Medicine, Fla. 33136.
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