This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fujii, K. Articles by Faraci, F. M. Search for Related Content PubMed PubMed Citation Articles by Fujii, K. Articles by Faraci, F. M.

Stroke, Vol 23, 1494-1498, Copyright © 1992 by American Heart Association

ARTICLES

Effect of diabetes mellitus on flow-mediated and endothelium-dependent dilatation of the rat basilar artery

K Fujii, DD Heistad and FM Faraci
Department of Internal Medicine, Veterans Administration Medical Center Iowa City, Iowa.

BACKGROUND AND PURPOSE: Diabetes mellitus may impair endothelium- dependent responses in cerebral arterioles. The basilar artery dilates in response to increases in blood flow. The goal of this study was to examine effects of diabetes mellitus on "flow-mediated" and endothelium- dependent dilatation of the basilar artery. METHODS: Diabetes was induced in rats with 50 mg/kg streptozotocin. Six months later, vessel diameter and velocity of blood flow through the basilar artery were measured using a cranial window in anesthetized rats under baseline conditions and during occlusion of the carotid arteries. Changes in vessel diameter were also measured during topical application of acetylcholine and sodium nitroprusside. RESULTS: With aortic pressure maintained at baseline levels, blood flow velocity through the basilar artery increased similarly in control and diabetic rats during unilateral common carotid artery occlusion and during bilateral occlusion. In control and diabetic rats, diameter of the basilar artery increased by 10 +/- 2% and 10 +/- 4% during unilateral occlusion and by 27 +/- 5% and 31 +/- 4% during bilateral occlusion, respectively. Thus, diabetes did not impair flow-mediated dilatation of the basilar artery. In contrast, dilatation in response to 10(-5) M topical acetylcholine was less in diabetic rats (13 +/- 2%) than in control rats (45 +/- 8%) (p less than 0.05). Dilator responses to nitroprusside were not impaired by diabetes. CONCLUSIONS: The findings suggest that diabetes produces impairment of endothelium-dependent responses to acetylcholine, but not flow-mediated dilatation, in the basilar artery.

This article has been cited by other articles:

				S. Cellek, P. N. Anderson, and N. A. Foxwell Nitrergic Neurodegeneration in Cerebral Arteries of Streptozotocin-Induced Diabetic Rats: A New Insight into Diabetic Stroke Diabetes, January 1, 2005; 54(1): 212 - 219. [Abstract] [Full Text] [PDF]

				A. K. Trauernicht, H. Sun, K. P. Patel, and W. G. Mayhan Enalapril Prevents Impaired Nitric Oxide Synthase-Dependent Dilatation of Cerebral Arterioles in Diabetic Rats Stroke, November 1, 2003; 34(11): 2698 - 2703. [Abstract] [Full Text] [PDF]

				R. M. Bryan Jr., S. P. Marrelli, M. L. Steenberg, L. A. Schildmeyer, and T. D. Johnson Effects of luminal shear stress on cerebral arteries and arterioles Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2011 - H2022. [Abstract] [Full Text] [PDF]

				F. R. L. Crijns, B. H. R. Wolffenbuttel, J. G. R. de Mey, and H. A. J. S. Boudier Mechanical properties of mesenteric arteries in diabetic rats: consequences of outward remodeling Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1672 - H1677. [Abstract] [Full Text] [PDF]

				W. G. Mayhan and K. P. Patel Treatment with dimethylthiourea prevents impaired dilatation of the basilar artery during diabetes mellitus Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H1895 - H1901. [Abstract] [Full Text] [PDF]

				C. Kimura, M. Oike, and Y. Ito Acute Glucose Overload Abolishes Ca2+ Oscillation in Cultured Endothelial Cells From Bovine Aorta : A Possible Role of Superoxide Anion Circ. Res., April 6, 1998; 82(6): 677 - 685. [Abstract] [Full Text] [PDF]

				F. M. FARACI and D. D. HEISTAD Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels Physiol Rev, January 1, 1998; 78(1): 53 - 97. [Abstract] [Full Text] [PDF]

				P. A. Zimmermann, H. J. Knot, A. S. Stevenson, and M. T. Nelson Increased Myogenic Tone and Diminished Responsiveness to ATP-Sensitive K+ Channel Openers in Cerebral Arteries From Diabetic Rats Circ. Res., December 19, 1997; 81(6): 996 - 1004. [Abstract] [Full Text]

				M. J. Cipolla, J. M. Porter, G. Osol, and W. G. Mayhan High Glucose Concentrations Dilate Cerebral Arteries and Diminish Myogenic Tone Through an Endothelial Mechanism Stroke, February 1, 1997; 28(2): 405 - 411. [Abstract] [Full Text]

				T. Kitazono, F. M. Faraci, H. Taguchi, and D. D. Heistad Role of Potassium Channels in Cerebral Blood Vessels Stroke, September 1, 1995; 26(9): 1713 - 1723. [Abstract] [Full Text]

				P. J. Nahser Jr, R. E. Brown, H. Oskarsson, M. D. Winniford, and J. D. Rossen Maximal Coronary Flow Reserve and Metabolic Coronary Vasodilation in Patients With Diabetes Mellitus Circulation, February 1, 1995; 91(3): 635 - 640. [Abstract] [Full Text]