Stroke, Vol 23, 242-246, Copyright © 1992 by American Heart Association
SA Mayer and WA Pulsinelli
BACKGROUND AND PURPOSE: Reports of improved short-term (less than 72 hours)
outcome in experimental models of mechanical and ischemic central nervous
system injury suggest that exogenous ganglioside administration may confer
a protective effect on neural tissue. We studied the effect of the
monosialoganglioside GM1 on cerebral infarction and edema in spontaneously
hypertensive rats subjected to permanent focal cerebral ischemia. METHODS:
GM1 or normal saline was injected intramuscularly once a day for 3 days
before and 30 and 120 minutes after occlusion of the right middle and
common carotid arteries. Following a 24-hour survival period, the volume of
infarction was measured by computer-assisted image analysis, and the extent
of edema was assessed by measurements of tissue water content and
hemispheric volume. RESULTS: Infarct volume was similar among the GM1-
treated (n = 10) and saline-treated (n = 10) rats (212 +/- 10 versus 220
+/- 13 microliters, respectively). In a second series of experiments, the
brain water content and edema volume of the ischemic right hemisphere in
GM1-treated rats (n = 10) did not differ from saline-treated controls (n =
10). CONCLUSIONS: GM1 ganglioside does not effectively reduce cerebral
infarction caused by permanent focal ischemia.
ARTICLES
Failure of GM1 ganglioside to influence outcome in experimental focal ischemia
Department of Neurology, Cornell University Medical College, New York, N.Y.
This article has been cited by other articles:
 |
|
 |
|
  A. Slivka, E. Murphy, and L. Horrocks Cerebral Edema After Temporary and Permanent Middle Cerebral Artery Occlusion in the Rat Stroke, June 1, 1995; 26(6): 1061 - 1066. [Abstract] [Full Text]
|
|