This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakane, M. Articles by Tamura, A. Search for Related Content PubMed PubMed Citation Articles by Nakane, M. Articles by Tamura, A.

Stroke, Vol 23, 328-332, Copyright © 1992 by American Heart Association

ARTICLES

Degeneration of the ipsilateral substantia nigra following cerebral infarction in the striatum

M Nakane, A Teraoka, R Asato and A Tamura
Department of Neurosurgery, Tokyo Metropolitan Bokuto Hospital, Japan.

BACKGROUND AND PURPOSE: In rats, degeneration of the ipsilateral substantia nigra occurs a few weeks after occlusion of the middle cerebral artery. The aim of this study was to clarify whether similar change is observed in stroke patients. METHODS: Eighteen patients with striatal infarction and six patients with cortical infarction in the territory of the middle cerebral artery were examined by means of sequential magnetic resonance imaging. RESULTS: In all patients with striatal infarction, T2-weighted images revealed a high-signal- intensity spot in the ipsilateral substantia nigra. Changes in the ipsilateral substantial nigra appeared at day 14 after stroke on average and then became less intense and smaller a few months after the stroke. By contrast, we observed no nigral changes in any patient with cortical infarction. CONCLUSIONS: The degenerative change in the ipsilateral substantia nigra initially found in the rat model similarly occurred in patients with striatal infarction. This remote change in the substantia nigra may represent magnetic resonance imaging detection of neuropathologic changes in this region through the striatonigral pathway.

This article has been cited by other articles:

				W.-J. Moon, D. G. Na, S. S. Kim, J. W. Ryoo, and E. C. Chung Diffusion Abnormality of Deep Gray Matter in External Capsular Hemorrhage AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 229 - 235. [Abstract] [Full Text] [PDF]

				M. Nakane, A. Tamura, N. Miyasaka, T. Nagaoka, and T. Kuroiwa Astrocytic Swelling in the Ipsilateral Substantia Nigra after Occlusion of the Middle Cerebral Artery in Rats AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 660 - 663. [Abstract] [Full Text]

				M. Fujioka, Y. Maeda, K. Okuchi, T. Kagoshima, and T. Taoka Secondary Change in the Substantia Nigra Induced by Incomplete Infarct and Minor Hemorrhage in the Basal Ganglia Due to Traumatic Middle Cerebral Arterial Dissection Stroke, September 1, 1999; 30 (9): 1974b - 1981. [Full Text] [PDF]

				P. A. LeWitt, M. Savoiardo, F. Girotti, and J. S. Kim Micrographia after thalamo-mesencephalic infarction Neurology, June 1, 1999; 52(9): 1920 - 1920. [Full Text]

				T. Beck, H.-J. Goller, and A. Wree Chronic Depression of Glucose Metabolism in Postischemic Rat Brains Stroke, June 1, 1995; 26(6): 1107 - 1113. [Abstract] [Full Text]