Stroke, Vol 23, 804-811, Copyright © 1992 by American Heart Association
PB Gorelick, A Chatterjee, D Patel, G Flowerdew, W Dollear, J Taber and Y Harris
BACKGROUND AND PURPOSE: We compared cranial computed tomography findings
among 58 multi-infarct dementia index cases and 74 multi- infarct control
subjects without cognitive impairment to identify potential determinants of
multi-infarct dementia. METHODS: The cranial computed tomography records of
acute ischemic stroke patients with a history of multiple cerebral infarcts
were compared to determine the number, location, and size of cerebral
infarcts; the pattern of infarction; brain volume loss; and the degree of
white matter lucency, sulcal enlargement, and ventricular enlargement.
Multi-infarct patients were divided into two groups: 1) index cases were
defined as those with multi-infarct dementia as defined by the Diagnostic
and Statistical Manual of Mental Disorders, edition 3 (DSM-III) criteria;
and 2) control subjects were defined as those multi-infarct patients
without dementia or multi-infarct dementia according to DSM-III criteria.
RESULTS: Overall, multi-infarct index cases had more cerebral infarcts,
more cortical and subcortical left hemisphere infarcts, higher mean
ventricular volume to brain volume ratio, more extensive enlargement of the
body of the lateral ventricles and cortical sulci, and a higher prevalence
of white matter lucencies. Among multi-infarct cases and control subjects
the most frequent site of infarction was the subcortical region, and the
most frequent pattern of infarction was lacunar. Stepwise logistic
regression analysis examined cranial computed tomography as well as other
factors and showed that level of education, stroke severity, left cortical
infarction, and diffuse enlargement of the left lateral ventricle were the
best overall predictors of multi-infarct dementia. CONCLUSIONS: Level of
education, stroke severity, and left hemisphere infarction may be
predictors of multi-infarct dementia.
ARTICLES
Cranial computed tomographic observations in multi-infarct dementia. A controlled study
Department of Neurology (Stroke, Alzheimer, and Neuroepidemiology Services), Michael Reese Hospital and Medical Center, School of Public Health (Epidemiology and Biometry Program), University of Illinois, Chicago, Chicago, IL.
This article has been cited by other articles:
 |
|
 |
|
  P. B. Gorelick William M. Feinberg Lecture: Cognitive Vitality and the Role of Stroke and Cardiovascular Disease Risk Factors Stroke, April 1, 2005; 36(4): 875 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fein, V. Di Sclafani, J. Tanabe, V. Cardenas, M. W. Weiner, W. J. Jagust, B. R. Reed, D. Norman, N. Schuff, L. Kusdra, et al. Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease Neurology, December 12, 2000; 55(11): 1626 - 1635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pohjasvaara, R. Mantyla, O. Salonen, H. J. Aronen, R. Ylikoski, M. Hietanen, M. Kaste, and T. Erkinjuntti How Complex Interactions of Ischemic Brain Infarcts, White Matter Lesions, and Atrophy Relate to Poststroke Dementia Arch Neurol, September 1, 2000; 57(9): 1295 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Desmond, J. T. Moroney, M. C. Paik, M. Sano, J. P. Mohr, S. Aboumatar, C.-L. Tseng, S. Chan, J. B. W. Williams, R. H. Remien, et al. Frequency and clinical determinants of dementia after ischemic stroke Neurology, March 14, 2000; 54(5): 1124 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Gorelick Cerebrovascular Disease in African Americans Stroke, December 1, 1998; 29(12): 2656 - 2664. [Full Text] [PDF]
|
|
|
|
 |
|
 J. V Bowler, D. G Munoz, H. Merskey, and V. Hachinski Fallacies in the pathological confirmation of the diagnosis of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, January 1, 1998; 64(1): 18 - 24. [Abstract] [Full Text]
|
|
|
|
|
|
J. V. Bowler, M. Eliasziw, R. Steenhuis, D. G. Munoz, R. Fry, H. Merskey, and V. C. Hachinski Comparative Evolution of Alzheimer Disease, Vascular Dementia, and Mixed Dementia Arch Neurol, June 1, 1997; 54(6): 697 - 703. [Abstract] [PDF]
|
|
|
|
|
|
P. B. Gorelick Status of Risk Factors for Dementia Associated With Stroke Stroke, February 1, 1997; 28(2): 459 - 463. [Abstract] [Full Text]
|
|
|
|
|
|
B. Censori, O. Manara, C. Agostinis, M. Camerlingo, L. Casto, B. Galavotti, T. Partziguian, M. C. Servalli, B. Cesana, G. Belloni, et al. Dementia After First Stroke Stroke, July 1, 1996; 27(7): 1205 - 1210. [Abstract] [Full Text]
|
|
|
|
|
|
T. Wetterling, R.-D. Kanitz, and K.-J. Borgis Comparison of Different Diagnostic Criteria for Vascular Dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN) Stroke, January 1, 1996; 27(1): 30 - 36. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Meyer, K. Muramatsu, K. F. Mortel, K. Obara, and T. Shirai Prospective CT Confirms Differences Between Vascular and Alzheimer's Dementia Stroke, May 1, 1995; 26(5): 735 - 742. [Abstract] [Full Text]
|
|
|
|
|
|
A. Corbett, H. Bennett, and S. Kos Cognitive Dysfunction Following Subcortical Infarction Arch Neurol, October 1, 1994; 51(10): 999 - 1007. [Abstract] [PDF]
|
|
|
|
|
|
D. Galasko, L. A. Hansen, R. Katzman, W. Wiederholt, E. Masliah, R. Terry, L. R. Hill, P. Lessin, and L. J. Thal Clinical-Neuropathological Correlations in Alzheimer's Disease and Related Dementias Arch Neurol, September 1, 1994; 51(9): 888 - 895. [Abstract] [PDF]
|
|
|
|
|
|
P. B. Gorelick, J. Brody, D. Cohen, S. Freels, P. Levy, W. Dollear, H. Forman, and Y. Harris Risk Factors for Dementia Associated With Multiple Cerebral Infarcts: A Case-Control Analysis in Predominantly African-American Hospital-Based Patients Arch Neurol, July 1, 1993; 50(7): 714 - 720. [Abstract] [PDF]
|
|