Stroke, Vol 24, 1484-1489, Copyright © 1993 by American Heart Association
LL Haheim, I Holme, I Hjermann and P Leren
BACKGROUND AND PURPOSE: The objective of this study was to determine the
risk factors of stroke incidence and mortality. METHODS: Our data are based
on a prospective cohort study of men aged 40 to 49 years after 12 years of
follow-up. RESULTS: In age-adjusted Cox proportional- hazards regression
analysis of 14,403 healthy men, diastolic blood pressure was a stronger
predictor for stroke incidence and mortality than systolic blood pressure.
Smoking was a stronger predictor of mortality than of incidence. However,
there was no dose-response relation among smokers by increased cigarette
consumption. Total serum cholesterol was a significant (P < .05) risk
factor for stroke mortality and of borderline significance (P = .08) for
stroke incidence. Increased physical activity at leisure was associated
with reduced stroke incidence but not mortality. The myocardial infarction
risk score comprising systolic blood pressure, total serum cholesterol, and
daily cigarette smoking was a strong predictor of mortality and incidence.
Body mass index, triglycerides, blood glucose, and physical activity at
work were not found to be risk factors for stroke. CONCLUSIONS: Reduction
of blood pressure, cessation of smoking, lowered cholesterol, and increased
physical activity at leisure are individual measures to reduce the risk of
stroke.
ARTICLES
Risk factors of stroke incidence and mortality. A 12-year follow-up of the Oslo Study
Life Insurance Companies Institute of Medical Statistics, Ulleval Hospital, Oslo, Norway.
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