Stroke, Vol 24, 1625-1630, Copyright © 1993 by American Heart Association
SE Starkstein, JP Fedoroff, TR Price, R Leiguarda and RG Robinson
BACKGROUND AND PURPOSE: Although apathy has been reported to constitute a
frequent sequela of stroke lesions, there have been no prospective studies
on the frequency and correlates of apathy after stroke lesions. In the
present study, we examined the frequency and correlates of apathy in a
consecutive series of 80 patients with cerebrovascular lesions. METHODS: We
included patients within the first 10 days after a stroke lesion. Patients
were examined with a comprehensive neuropsychiatric battery that included
the Apathy Scale. RESULTS: Eighteen patients (22.5%) showed apathy, nine of
whom were also depressed. On the other hand, 18 patients (22.5%) showed
depression in the absence of apathy. Although depression and apathy may
exist independent of one another, major depression (but not minor
depression) was associated with an increased frequency of apathy. Apathy
was also significantly associated with older age, cognitive impairments,
and deficits in activities of daily living. Finally, apathy was
significantly associated with lesions in the posterior limb of the internal
capsule. CONCLUSIONS: These findings demonstrate that apathy is a frequent
finding among patients with acute stroke lesions and may coexist with
important emotional and cognitive poststroke disturbances.
ARTICLES
Apathy following cerebrovascular lesions
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Md.
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