Stroke, Vol 24, 1631-1634, Copyright © 1993 by American Heart Association
T Fujikawa, S Yamawaki and Y Touhouda
BACKGROUND AND PURPOSE: There have been few studies of the incidence of
silent cerebral infarction detected by magnetic resonance imaging in
patients with presenile or senile major depression. METHODS: We examined
silent cerebral infarction in patients with presenile and senile major
depression who were diagnosed at Hiroshima Prefectural Hospital. The
diagnostic criteria of the American Psychiatric Association (DSM-III-R)
were used. Patients with stroke or focal neurological symptoms were
excluded. RESULTS: Silent cerebral infarction was observed in 51.4% of the
patients with presenile-onset presenile depression, and the incidence was
significantly higher than in patients with juvenile-onset presenile
depression (P < .01). Among the patients with senile major depression,
silent cerebral infarction was observed in 65.9% of those with
presenile-onset depression and in 93.7% of those with senile-onset
depression. CONCLUSIONS: Our findings suggest that half of presenile-onset
major depression and the majority of senile-onset major depression might be
organic depression related to silent cerebral infarction. Because major
depression occurring for the first time during or after the presenile
period may be related to silent cerebral infarction, it is important to
keep this possibility in mind when treating such patients.
ARTICLES
Incidence of silent cerebral infarction in patients with major depression
Department of Neurology and Psychiatry, Hiroshima University School of Medicine, Japan.
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